Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia

NK Binder; FC Brownfoot; S Beard; P Cannon; TV Nguyen; S Tong; TJ Kaitu'u-Lino; NJ Hannan

Journal article

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia

NK Binder, FC Brownfoot, S Beard, P Cannon, TV Nguyen, S Tong, TJ Kaitu'u-Lino, NJ Hannan

Pregnancy Hypertension | ELSEVIER SCI LTD | Published : 2020

DOI: 10.1016/j.preghy.2020.07.013

Abstract

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance for the obstetrics field. We recently identified esomeprazole and sulfasalazine as potential candidates for the treatment of preeclampsia. Both reduce placental and endothelial secretion of sFlt-1 and sENG and mitigate endothelial dysfunction in vitro. Here we assessed whether esomeprazole and sulfasalazine in combination would additively attenuate the elevated release of anti-angiogenic factors and markers of endothelial dysfunction, key characteristics of preeclampsia. Primary placental tissue and cells, and primary endothelial cells were treated with esomepraz..

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University of Melbourne Researchers

Natalie Binder Author

Fiona Brownfoot Author

Ping Cannon Author

Vi Nguyen Author

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Grants

Awarded by Norman Beischer Medical Research Foundation

Funding Acknowledgements

This study was funded by the Norman Beischer Medical Research Foundation and a grant from the National Health and Medical Research Council of Australia (NHMRC #1101871). The NHMRC also provided salary support (TKL; #1159261 FB; #1142636 ST; #1136418 and NJH; #1146128). The funders had no role in study design, data collection, analysis or decision to publish.